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Test Code DMNES Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum


Ordering Guidance


Multiple neurological phenotype-specific autoimmune/paraneoplastic evaluations are available. For more information as well as phenotype-specific testing options, refer to Autoimmune Neurology Test Ordering Guide.

 

For a list of antibodies performed with each evaluation, see Autoimmune Neurology Antibody Matrix.



Specimen Required


Patient Preparation: For optimal antibody detection, specimen collection is recommended to occur prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Secondary ID

621103

Useful For

Evaluating patients with a suspected immune-mediated demyelinating peripheral neuropathy

Profile Information

Test ID Reporting Name Available Separately Always Performed
DMNI Demyelinating Neuropathy Interp, S No Yes
CONCS Contactin-1 IgG CBA, S No Yes
GQ1ES GQ1b-IgG ELISA, S Yes Yes
IGG_D IgG Disialo. GD1b No Yes
IGM_D IgM Disialo. GD1b No Yes
IGG_M IgG Monos. GM1 No Yes
IGM_M IgM Monos. GM1 No Yes
MAGES MAG IgM, S Yes Yes
NF4FS Neurofascin-155 IgG4, S No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IGDTS IgG Disialo GD1b Titer, S No No
IMDTS IgM Disialo GD1b Titer, S No No
IGMTS IgG Monos GM1 Titer, S No No
IMMTS IgM Monos GM1 Titer, S No No

Testing Algorithm

Screening tests are performed for IgG and IgM antibodies to GM1 and GD1b. If positive, the appropriate titer will be performed at an additional charge.

 

For more information see:

-Demyelinating Neuropathy Evaluation Algorithm.

-Acquired Neuropathy Diagnostic Algorithm

Method Name

DMNI: Technical Interpretation

CONCS: Cell-Binding Assay (CBA)

GQ1ES, IGG_D, IGM_D, IGG_M, IGM_M, IGDTS, IMDTS, IGMTS, IMMTS, MAGES: Enzyme-Linked Immunosorbent Assay (ELISA)

NF4FS: Flow Cytometry

Reporting Name

Demyelinating Neuropathy Ab Eval, S

Specimen Type

Serum

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Contactin-1 IgG CBA: Negative

GQ1b-IgG ELISA: Negative

IgG Disialo. GD1b: Negative

IgM Disialo. GD1b: Negative

IgG Monos. GM1: Negative

IgM Monos. GM1: Negative

MAG IgM: <1500 Buhlmann titer unit

Neurofascin-155 IgG4: Negative

 

Reflex Information:

IgG Disialo GD1b Titer: <1:2000

IgM Disialo GD1b Titer: <1:2000

IgG Monos GD1b Titer: <1:2000

IgM Monos GD1b Titer: <1:4000

Day(s) Performed

Monday through Sunday

Report Available

5 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83516 x5

83520

86255 x2

83520 x4 (if applicable)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DMNES Demyelinating Neuropathy Ab Eval, S 82455-7

 

Result ID Test Result Name Result LOINC Value
621107 GQ1b-IgG ELISA, S 63254-7
621104 Demyelinating Neuropathy Interpretation, S 69048-7
4416 IgG Disialo. GD1b 94868-7
4412 IgG Monos. GM1 63243-0
4417 IgM Disialo. GD1b 94870-3
4413 IgM Monos. GM1 63247-1
607034 MAG IgM, S 39087-2
614591 Neurofascin-155 IgG4, S 100845-7
616442 Contactin-1 IgG CBA, S 101448-9